|
Waist Circumference
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.
|
28552196 |
2017 |
|
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We describe that the transmembrane receptor PTPκ (RPTPκ), encoded by the transforming growth factor (TGF) β-target gene, PTPRK, promotes RA FLS invasiveness.
|
25378349 |
2016 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Two CRCs contained EIF3E-RSPO2 fusion transcripts, and another CRC contained PTPRK-RSPO3 fusion transcripts.
|
24847761 |
2014 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Thus, identifying PTPRK substrates provides insight into its downstream signaling and a potential molecular explanation for its proposed tumor suppressor function.
|
30924770 |
2019 |
|
Malignant Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
The present study is the first study providing evidence of several genetic variants within the PTPRK gene associated with the risk and AAO of AD, risk of cancer, LDL and total cholesterol levels.
|
28987514 |
2018 |
|
Primary malignant neoplasm
|
0.040 |
GeneticVariation
|
group |
BEFREE |
The present study is the first study providing evidence of several genetic variants within the PTPRK gene associated with the risk and AAO of AD, risk of cancer, LDL and total cholesterol levels.
|
28987514 |
2018 |
|
Colorectal Traditional Serrated Adenoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The present study identified RSPO fusion transcripts, including three novel transcripts, in one-third of colorectal TSAs and showed that PTPRK-RSPO3 fusions were the predominant cause of RSPO overexpression in colorectal TSA.
|
28543708 |
2017 |
|
Malignant neoplasm of prostate
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
The expression of the PTPRK protein and transcript in prostate cancer was examined using IHC and PCR.
|
24002526 |
2013 |
|
Prostate carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of the PTPRK protein and transcript in prostate cancer was examined using IHC and PCR.
|
24002526 |
2013 |
|
Adolescent idiopathic scoliosis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
|
SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
TGF-beta up-regulated PTPRK mRNA and RPTPkappa (receptor type protein tyrosine phosphatase kappa, the protein product encoded by the PTPRK gene) protein in tumor and nontumor mammary cells; HER2 overexpression down-regulated its expression.
|
15899872 |
2005 |
|
Intelligence
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
|
29844566 |
2018 |
|
Squamous cell carcinoma of the head and neck
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Significantly, the practicability of AlloDriver to discover novel cancer driver proteins in head and neck squamous cell carcinoma (HNSC) was tested in a real case of human protein tyrosine phosphatase, receptor type K (PTPRK) through a L1143F driver mutation located at the allosteric site of PTPRK, which was experimentally validated by cell proliferation assay.
|
31069394 |
2019 |
|
Malignant Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
Significantly, the practicability of AlloDriver to discover novel cancer driver proteins in head and neck squamous cell carcinoma (HNSC) was tested in a real case of human protein tyrosine phosphatase, receptor type K (PTPRK) through a L1143F driver mutation located at the allosteric site of PTPRK, which was experimentally validated by cell proliferation assay.
|
31069394 |
2019 |
|
Primary malignant neoplasm
|
0.040 |
GeneticVariation
|
group |
BEFREE |
Significantly, the practicability of AlloDriver to discover novel cancer driver proteins in head and neck squamous cell carcinoma (HNSC) was tested in a real case of human protein tyrosine phosphatase, receptor type K (PTPRK) through a L1143F driver mutation located at the allosteric site of PTPRK, which was experimentally validated by cell proliferation assay.
|
31069394 |
2019 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.
|
31619474 |
2019 |
|
Allergic Reaction
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.
|
29083406 |
2017 |
|
Neoplasms
|
0.060 |
GeneticVariation
|
group |
BEFREE |
Several genetic changes including BCL6 rearrangements and deletion of 6q22, containing the putative tumor suppressor gene PTPRK, are potential risk predictors.
|
18645192 |
2008 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Reverse transcription-PCR analysis of the mRNA from 4 cases with 6q deletions confirmed loss of this gene, and loss of PTPRK expression was observed in 76% (22 of 29) of tumors with immunohistochemistry.
|
12591717 |
2003 |
|
Traditional Serrated Adenoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Reverse transcription PCR identified previously reported PTPRK-RSPO3 fusion transcripts in all 29 TSAs with RSPO3 overexpression, confirming that PTPRK-RSPO3 is the predominant RSPO fusion in TSAs.
|
30916365 |
2019 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Restoration of PTPRK inhibited tumor cell growth and reduced the migration and invasion ability of NKTCL cells.
|
25612622 |
2015 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Restoration of PTPRK inhibited tumor cell growth and reduced the migration and invasion ability of NKTCL cells.
|
25612622 |
2015 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Recurrent, gain-of-expression gene fusions of RSPO2 (to EIF3E) and RSPO3 (to PTPRK) occur in a subset of human colorectal cancer.
|
25531322 |
2015 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recurrent, gain-of-expression gene fusions of RSPO2 (to EIF3E) and RSPO3 (to PTPRK) occur in a subset of human colorectal cancer.
|
25531322 |
2015 |